Associations of genetic variants of miRNA coding regions with pulmonary tuberculosis risk in China

Tuberculosis (TB) is the leading cause of death caused by single pathogenic microorganism, Mycobacterium tuberculosis (MTB). The study aims to explore associations microRNA (miRNA) single-nucleotide polymorphisms (SNPs) with pulmonary TB (PTB) risk. A population-based case−control was conducted, and 168 newly diagnosed smear-positive PTB cases 251 non-TB controls were recruited. SNPs located within miR-27a (rs895819), miR-423 (rs6505162), miR-196a-2 (rs11614913), miR-146a (rs2910164), miR-618 (rs2682818) selected MassARRAY® MALDI-TOF System employed for genotyping. SPSS19.0 adopted statistical analysis, non-conditional logistic regression performed. Odds ratios (ORs) 95% confidence intervals (95% CIs) computed estimate associations. Associations haplotypes risk performed online tool. Rs895819 CT/CC genotype associated reduced among female population (OR = 0.45, CI: 0.23–0.98), P 0.045. Haplotypes (combined rs895819, rs2682818, rs2910164, rs6505162 rs11614913) TCCCT, TAGCC, CCCCC, CCGCT TCGAT ORs 0.67 0.45–0.99), 0.49 (0.25–0.94), 0.34 0.14–0.81), 0.22 0.06–0.84) 0.24 0.07–0.79), respectively; while TAGCT, CCCCT, CACCT TCCAT increased risk, 3.63 1.54–8.55), 2.20 1.00–4.86), 3.90 1.47–10.36) 2.95 1.09–7.99), respectively. haplotype